RNF113A Promotes Colorectal Cancer Metastasis by Regulating TGF-β Pathway and EMT via Ubiquitin-Mediated Degradation of SNIP1
Kaoyan Feng, Mengbin Qin, Peng Peng, Wenfang Yang, Xiaoping Pan, Yanlin Tan, Sijie Yang, Jiean Huang, Jinxiu Zhang · 2026
Read RNF113A Promotes Colorectal Cancer Metastasis by Regulating TGF-β Pathway and EMT via Ubiquitin-Mediated Degradation of SNIP1 by Kaoyan Feng, Mengbin Qin, Peng Peng, Wenfang Yang, Xiaoping Pan, Yanlin Tan, Sijie Yang, Jiean Huang, Jinxiu Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13635658.txt.
Description
Kaoyan Feng and co-authors report a 2026 lab study on a protein called RNF113A and its role in colorectal cancer spread. The protein is found at higher levels in this cancer. The team asked whether it acts on a second protein, SNIP1, which normally holds back a growth signal pathway tied to how the disease advances.
Using patient tissue samples and cancer cells in dishes, the team found that high RNF113A went with low SNIP1. Extra RNF113A helped cells grow in colonies and move, while cutting it back raised SNIP1 levels. Tests showed the first protein tags the second one for breakdown. The authors name RNF113A as a possible drug target, while noting that more proof is still needed.
Catalog record
| CREATOR | Kaoyan Feng, Mengbin Qin, Peng Peng, Wenfang Yang, Xiaoping Pan, Yanlin Tan, Sijie Yang, Jiean Huang, Jinxiu Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |