The clinical and molecular landscape of thalamic glioma
Linpeng Zhang, Hesong Wang, Guangrui Huang, Xueling Qi, Angel M Carcaboso, Chen Wang, Jing Feng, Song Han, Zhilong Cheng, Zhong Ma, Yakun Yang, Heng Xu · 2026
Read The clinical and molecular landscape of thalamic glioma by Linpeng Zhang, Hesong Wang, Guangrui Huang, Xueling Qi, Angel M Carcaboso, Chen Wang, Jing Feng, Song Han, Zhilong Cheng, Zhong Ma, Yakun Yang, Heng Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13635587.txt.
Description
Linpeng Zhang and colleagues mapped the genetics and surgical outcomes of thalamic gliomas, tumors growing deep in the brain's relay center. These tumors press against vital pathways and resist both diagnosis and treatment. The team analyzed one hundred six tumors, split between a diffuse midline type and other forms. They combined gene profiling, single-cell readings, and careful statistical methods that mimic controlled comparisons for surgery questions.
Two genetic changes never appeared together: a histone gene mutation and loss of a small chromosome segment. That absence makes the segment loss a useful clue favoring the non-midline type. One surgical drainage procedure cut later water-on-the-brain complications by well over half. The front approach to the tumor independently predicted weakness afterward. Patients lived a median of about twenty-one months after resection. How much tumor surgeons removed and the mutation load mattered most for survival.
Catalog record
| CREATOR | Linpeng Zhang, Hesong Wang, Guangrui Huang, Xueling Qi, Angel M Carcaboso, Chen Wang, Jing Feng, Song Han, Zhilong Cheng, Zhong Ma, Yakun Yang, Heng Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |