Targeting PGAM1 Y119 phosphorylation resensitizes non-small-cell lung cancer to cisplatin therapy by promoting oxidative stress and DNA damage
Wenxia Zhang, Yanzhao Qu, Xin Wang, Lihua Wang, Xin Jin, Jiahui Kuang, Qian Wang, Shunxin Han, Min Wei, Yang Wang, Jia Liu · 2026
Read Targeting PGAM1 Y119 phosphorylation resensitizes non-small-cell lung cancer to cisplatin therapy by promoting oxidative stress and DNA damage by Wenxia Zhang, Yanzhao Qu, Xin Wang, Lihua Wang, Xin Jin, Jiahui Kuang, Qian Wang, Shunxin Han, Min Wei, Yang Wang, Jia Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13635264.txt.
Description
Lung tumors that survive the chemotherapy drug cisplatin often lean on a sugar-burning enzyme to clean up the damage. Wenxia Zhang and co-authors pinpointed in 2026 a single chemical tag on that enzyme, PGAM1, that switches its activity up. The tag ran high in patient tumors and higher still in drug-resistant cell lines.
Removing the tag's site made resistant cells sensitive again, in dishes and in animals. With the tag on, the enzyme funnels sugar into pathways that build DNA parts and mop up harmful oxygen, blunting the drug. A decoy peptide that blocks the tagging slowed resistant tumors in animals. The authors propose the tag as a drug target for restoring cisplatin's punch.
Catalog record
| CREATOR | Wenxia Zhang, Yanzhao Qu, Xin Wang, Lihua Wang, Xin Jin, Jiahui Kuang, Qian Wang, Shunxin Han, Min Wei, Yang Wang, Jia Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |