miR-125a-5p inhibits NF-κB by negatively regulating TRAF2 to alleviate inflammatory injury in ischemic stroke rats
Shourui Niu, Chujia Guo, Jinfen Zhang, Chunyan Li, Heng Zhu, Hongyu Liao, Jinwei Yang, Wei Ma, Liyan Li · 2026
Read miR-125a-5p inhibits NF-κB by negatively regulating TRAF2 to alleviate inflammatory injury in ischemic stroke rats by Shourui Niu, Chujia Guo, Jinfen Zhang, Chunyan Li, Heng Zhu, Hongyu Liao, Jinwei Yang, Wei Ma, Liyan Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13634409.txt.
Description
Shourui Niu and eight colleagues studied a tiny RNA molecule that calms brain inflammation after stroke in rats. Ischemic stroke blocks blood flow to part of the brain, and the returning blood triggers inflammatory injury on top of the original damage. Sequencing of rat cortex pointed the team to the molecule miR-125a-5p, which sat inside inflammation-related pathways. They raised its levels in rats and measured brain damage, movement problems, and cell death.
Treated rats showed smaller damaged areas, fewer dying cortex cells, and better neurological scores. The molecule works by reining in a protein called TRAF2, a switch in an inflammatory chain. Levels of that switch and its downstream partners fell in the cortex. Inflammatory messengers in the blood fell as well. The authors conclude that this small RNA protects the injured brain by quieting a central inflammation pathway, marking a possible direction for stroke therapy research.
Catalog record
| CREATOR | Shourui Niu, Chujia Guo, Jinfen Zhang, Chunyan Li, Heng Zhu, Hongyu Liao, Jinwei Yang, Wei Ma, Liyan Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| LICENSE | http://creativecommons.org/licenses/by/4.0/). |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |