Association between salivary alkaline phosphatase levels and periodontal disease: a systematic review and meta-analysis
Mario Alberto Alarcón-Sánchez, Sarah Monserrat Lomelí-Martínez, Daniel Ortuño-Sahagún, Julieta Sarai Becerra-Ruiz, Seyed Ali Mosaddad, Artak Heboyan · 2026
Read Association between salivary alkaline phosphatase levels and periodontal disease: a systematic review and meta-analysis by Mario Alberto Alarcón-Sánchez, Sarah Monserrat Lomelí-Martínez, Daniel Ortuño-Sahagún, Julieta Sarai Becerra-Ruiz, Seyed Ali Mosaddad, Artak Heboyan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13634036.txt.
Description
Mario Alberto Alarcon-Sanchez and co-authors pool studies on a saliva enzyme as a gum disease marker in a 2026 review. Alkaline phosphatase rises with tissue turnover, so saliva levels might flag periodontitis without a probe or scan. The team gathered twenty studies covering about fourteen hundred sixty people, with twelve fit for pooled math.
Saliva levels in gum inflammation alone matched healthy controls, and the two disease stages did not differ from each other either. Full periodontitis, though, ran clearly higher than healthy mouths. The catch is wide disagreement between studies and very low overall certainty. The authors call for standardized, better designed work before the test earns clinical trust.
Catalog record
| CREATOR | Mario Alberto Alarcón-Sánchez, Sarah Monserrat Lomelí-Martínez, Daniel Ortuño-Sahagún, Julieta Sarai Becerra-Ruiz, Seyed Ali Mosaddad, Artak Heboyan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |