Superinfection Exclusion Between Japanese Encephalitis Virus Genotypes I and III Occurs During Viral Entry
Hung-Han Hsu, Quan-Dong Peng, Shyan-Song Chiou, Yi-Chin Fan, Ruey-Yi Chang · 2026
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Description
A cell already fighting one virus often refuses a second, a phenomenon called superinfection exclusion. Hung-Han Hsu and co-authors tested it between two genotypes of Japanese encephalitis virus, which have been trading dominance in Asia. In both mammal and mosquito cells, the first genotype in blocked the other, in both directions.
The block happened at the door: the second virus could not get inside. It grew stronger the longer the first infection had to settle in. Normal cell uptake of other cargo continued, so the cells were not simply shut down. The authors suggest this quiet duel may help explain why one genotype has been replacing the other in the wild.
Catalog record
| CREATOR | Hung-Han Hsu, Quan-Dong Peng, Shyan-Song Chiou, Yi-Chin Fan, Ruey-Yi Chang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |