Identification of a Novel Subtype‐Derived Prognostic Signature Based on Nucleotide Metabolism‐Related Molecular Classification for Predicting Lung Adenocarcinoma Prognosis
Yue Shi, Shanshan Li, Lin Zhao, Yali Li, Fangyu Cai, Kun Wang, Naibo Xu, Benkun Liu, Fucheng Zhou, Yue Cui, Changguo Shi, Xue Bai, Jian Zhang, Shangke Huang · 2026
Read Identification of a Novel Subtype‐Derived Prognostic Signature Based on Nucleotide Metabolism‐Related Molecular Classification for Predicting Lung Adenocarcinoma Prognosis by Yue Shi, Shanshan Li, Lin Zhao, Yali Li, Fangyu Cai, Kun Wang, Naibo Xu, Benkun Liu, Fucheng Zhou, Yue Cui, Changguo Shi, Xue Bai, Jian Zhang, Shangke Huang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13633477.txt.
Description
A team in China builds a gene score to forecast lung cancer outcomes in a 2026 paper. The cancer type is lung adenocarcinoma, the main form of non small cell lung cancer. Genes that run nucleotide metabolism, the supply of DNA building blocks, may drive growth and shape the immune scene.
The team sorted tumors into three subtypes by those genes, then mined the subtype gaps for a score. Nine genes made the final signature, picked in a training split and checked in two more cohorts. The study also maps immune entry, mutations, and drug response by score. Lab tests on one gene in lung cells probe its role in tumor acts.
Catalog record
| CREATOR | Yue Shi, Shanshan Li, Lin Zhao, Yali Li, Fangyu Cai, Kun Wang, Naibo Xu, Benkun Liu, Fucheng Zhou, Yue Cui, Changguo Shi, Xue Bai, Jian Zhang, Shangke Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |