Pharmacological modulation of GPR84 revealed by dual states structures and immune functional assays
Myung Kyung Choi, Dong Jin Park, Pankyung Kim, Hee Seong Choi, Sorin Myung, Youngki Yoo, Nienping Chang, Ga-Yeon Yoon, Hye Jin Kang, Sang-Jun Ha, Hyun-Soo Cho · 2026
Read Pharmacological modulation of GPR84 revealed by dual states structures and immune functional assays by Myung Kyung Choi, Dong Jin Park, Pankyung Kim, Hee Seong Choi, Sorin Myung, Youngki Yoo, Nienping Chang, Ga-Yeon Yoon, Hye Jin Kang, Sang-Jun Ha, Hyun-Soo Cho (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13633242.txt.
Description
Myung Kyung Choi and ten co-authors map how a fatty-acid receptor switches on and off. Their 2026 paper solves both states of GPR84, an immune cell receptor. The receptor answers medium-chain fatty acids and stokes inflammation. Drug makers lacked its off-state structure for rational design.
Cryo-electron microscopy froze the receptor with a blocker and with an activator. The blocked form shows a loop lid and a plugged sodium site. Simulations found a side gate between two helices. The active form rearranges its toggle switch instead. In immune cells, the activator raised cytokine output, and the blocker erased it. Mutations confirmed the grip points. Pathway-selective drugs now have a blueprint.
Catalog record
| CREATOR | Myung Kyung Choi, Dong Jin Park, Pankyung Kim, Hee Seong Choi, Sorin Myung, Youngki Yoo, Nienping Chang, Ga-Yeon Yoon, Hye Jin Kang, Sang-Jun Ha, Hyun-Soo Cho |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |