Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases
Miao Sun, Dengju Li, Jia Wei · 2026
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Description
Miao Sun, Dengju Li, and Jia Wei review drugs that block Bruton's tyrosine kinase, a switch inside B cells. Their review was published in twenty twenty-six. The switch relays signals from many receptors and steers B cell growth, movement, and inflammation.
Blocking it has reshaped care for B cell cancers. The drug family now spans several designs: firm-binding, loose-binding, dual-target, and degrader types. The review covers how the switch works, how the drugs are classed, and how cancers escape them. It also weighs pairings with cell therapy, checkpoint drugs, and other targeted agents, plus stem cell transplant. Uses beyond cancer are charted too. The authors draw the whole arc into one reference.
Catalog record
| CREATOR | Miao Sun, Dengju Li, Jia Wei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 158 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |