Development of a clinical prediction model using volatile organic compounds as breath biomarkers in squamous oesophageal neoplasms: ViSON, protocol for a multicentre case–control study in UK NHS hospitals
Sameera Sharma, James Murray, Aaron Parker, Sara Jamel, Stefan Antonowicz, Adele Phillips, Elaine Bailey, Lyn Fox, Christine Plant, Valerio Converso, James K Ellis, Somnath Mukherjee · 2026
Read Development of a clinical prediction model using volatile organic compounds as breath biomarkers in squamous oesophageal neoplasms: ViSON, protocol for a multicentre case–control study in UK NHS hospitals by Sameera Sharma, James Murray, Aaron Parker, Sara Jamel, Stefan Antonowicz, Adele Phillips, Elaine Bailey, Lyn Fox, Christine Plant, Valerio Converso, James K Ellis, Somnath Mukherjee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13629980.txt.
Description
Sameera Sharma and thirty-five colleagues, with the ViSON collaborators, lay out a plan for a breath test for one cancer. The target is oesophageal squamous cell cancer. This form drives most of the world's deaths from oesophageal cancer. In Britain most cases surface late, when survival is poor. A breath-based shortcut could send the right patients to endoscopy sooner.
The study will recruit 518 people across NHS hospitals. Half will have the cancer. Half will be cancer-free controls. Breath samples travel on sorbent tubes to a central lab for chemical analysis. A prediction model will be built from the breath compounds. It will be checked for accuracy, calibration, and clinical usefulness. The design targets high sensitivity with solid specificity.
Catalog record
| CREATOR | Sameera Sharma, James Murray, Aaron Parker, Sara Jamel, Stefan Antonowicz, Adele Phillips, Elaine Bailey, Lyn Fox, Christine Plant, Valerio Converso, James K Ellis, Somnath Mukherjee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |