Molecular insights into triazole-based compounds for triple-negative breast cancer treatment
Ahamed Vilangalil, Sindhu Priya E S, Sarad Pawar Naik Bukke, Sandhya V, Nafeesa Meha, Chandrashekar Thalluri, Kasolo Daniel, Allan Amooti Ahikiriza · 2026
Read Molecular insights into triazole-based compounds for triple-negative breast cancer treatment by Ahamed Vilangalil, Sindhu Priya E S, Sarad Pawar Naik Bukke, Sandhya V, Nafeesa Meha, Chandrashekar Thalluri, Kasolo Daniel, Allan Amooti Ahikiriza (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13629804.txt.
Description
Ahamed Vilangalil and seven colleagues review triazole compounds as candidate treatments for triple-negative breast cancer, the aggressive subtype that lacks the hormone and HER2 receptors most targeted drugs exploit. Triazoles appeal because their ring structure is stable, versatile, and able to engage several biological targets at once.
The review organises the evidence on how these compounds kill tumour cells: triggering programmed death, halting the cell cycle, blocking blood vessel growth and spread, and interfering with major cancer signaling pathways. Natural and synthetic versions are compared through structure-activity relationships, and computational tools such as docking and virtual screening get credit for speeding the search. Remaining challenges include overcoming drug resistance in the clinic.
Catalog record
| CREATOR | Ahamed Vilangalil, Sindhu Priya E S, Sarad Pawar Naik Bukke, Sandhya V, Nafeesa Meha, Chandrashekar Thalluri, Kasolo Daniel, Allan Amooti Ahikiriza |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |