Systematic Structure–Activity Relationship Investigation on Novel 5‑Alkyl-6-benzyl-2-{[(methylthio/phenylthio)alkyl]thio}-pyrimidin-4(3H)‑ones Endowed with Potent Anti-HIV‑1 Activity
Gebremedhin Solomon Hailu, Egor Degtyarenko, Emanuele Fabbrizi, Anastasia Golovina, Andrey Voronkov, Andrea Mancini, Maxim B. Nawrozkij, Vladimir Chernyshov, Laura Bavagnoli, Elena Bianchi, Roberta Astolfi, Rino Ragno, José A. Esté, Emmanuele Crespan, Francesco Fiorentino, Roman Ivanov, Antonello Ma · 2026
Read Systematic Structure–Activity Relationship Investigation on Novel 5‑Alkyl-6-benzyl-2-{[(methylthio/phenylthio)alkyl]thio}-pyrimidin-4(3H)‑ones Endowed with Potent Anti-HIV‑1 Activity by Gebremedhin Solomon Hailu, Egor Degtyarenko, Emanuele Fabbrizi, Anastasia Golovina, Andrey Voronkov, Andrea Mancini, Maxim B. Nawrozkij, Vladimir Chernyshov, Laura Bavagnoli, Elena Bianchi, Roberta Astolfi, Rino Ragno, José A. Esté, Emmanuele Crespan, Francesco Fiorentino, Roman Ivanov, Antonello Ma (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13629370.txt.
Description
Gebremedhin Hailu and co-authors map in 2026 structure changes in pyrimidinone compounds that fight HIV. Four series vary at three ring spots and face virus tests in cells. Harm to cells stays low to moderate across the set.
Two halogen picks on one ring arm lead the potency ranks. Lead compounds beat two standard drugs and match a third on strength. They also hold up better against drug-proof virus variants. Selectivity runs high for the two lead picks in the assays. Cell assays in a standard host line grade all four series.
Catalog record
| CREATOR | Gebremedhin Solomon Hailu, Egor Degtyarenko, Emanuele Fabbrizi, Anastasia Golovina, Andrey Voronkov, Andrea Mancini, Maxim B. Nawrozkij, Vladimir Chernyshov, Laura Bavagnoli, Elena Bianchi, Roberta Astolfi, Rino Ragno, José A. Esté, Emmanuele Crespan, Francesco Fiorentino, Roman Ivanov, Antonello Ma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |