Protocol for repeated Plasmodium chabaudi infection in a murine malaria model
Federica Bruno, Jean Langhorne, Cristina Lo Celso · 2026
Read Protocol for repeated Plasmodium chabaudi infection in a murine malaria model by Federica Bruno, Jean Langhorne, Cristina Lo Celso (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13629323.txt.
Description
Federica Bruno and two colleagues give a step-by-step protocol for infecting lab mice with a rodent malaria parasite. The parasite is Plasmodium chabaudi. People in malaria regions are infected again and again across a life. The protocol copies that pattern. Researchers can then study how immunity builds, and what it costs the host.
The method covers a first infection and full natural recovery. No malaria drugs are used. A second infection follows. Each stage is set out in detail. Letting the mice clear the parasite themselves is the point. It mirrors how partial immunity forms in humans. Hidden costs come with it, such as lasting anaemia. The authors frame the method as a shared platform. Labs studying long-term responses to repeated malaria can all use it.
Catalog record
| CREATOR | Federica Bruno, Jean Langhorne, Cristina Lo Celso |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |