Total Syntheses and Structural Reassignment of Ugonin T and Neougonin B: Anti-inflammatory Flavonoids Related to Helminthostachys zeylanica
Yuh-Chiang Shen, Chang-Hui Chen, San-Yao Su, Yi-Jyung Lin, Zhong-You Lai, Cheng-Ming Chen, Chun-Wei Chen, Fei-Pei Kao, Ming-Jaw Don, Yea-Hwey Wang · 2026
Read Total Syntheses and Structural Reassignment of Ugonin T and Neougonin B: Anti-inflammatory Flavonoids Related to Helminthostachys zeylanica by Yuh-Chiang Shen, Chang-Hui Chen, San-Yao Su, Yi-Jyung Lin, Zhong-You Lai, Cheng-Ming Chen, Chun-Wei Chen, Fei-Pei Kao, Ming-Jaw Don, Yea-Hwey Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13628622.txt.
Description
When chemists finally build a natural product in the lab, the molecule sometimes turns out to have been drawn wrong for years. Yuh-Chiang Shen and co-authors report exactly that outcome in a 2026 paper on anti-inflammatory flavonoids from a fern relative. They completed the first total syntheses of ugonin C and ugonin F, and built the originally proposed structures of two relatives.
Comparing synthetic samples with the natural ones forced a structural reassignment: ugonin T and neougonin B are different compounds than first drawn. A small library of analogues came along for the ride. Several showed strong anti-inflammatory action in microglial cells, with one analogue the most potent of the set. Synthesis here did double duty, correcting the record and stocking the medicine shelf.
Catalog record
| CREATOR | Yuh-Chiang Shen, Chang-Hui Chen, San-Yao Su, Yi-Jyung Lin, Zhong-You Lai, Cheng-Ming Chen, Chun-Wei Chen, Fei-Pei Kao, Ming-Jaw Don, Yea-Hwey Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |