Identification of Gβ5 Interactome Associated with Neuronal Development in Neuro-2a Cells through miniTurbo Proximity Labeling
Harrison J. McNabb, Jianhua Zhang, Connor P. Jewell, Weiming Yang, Lisa M. Jenkins, William F. Simonds · 2026
Read Identification of Gβ5 Interactome Associated with Neuronal Development in Neuro-2a Cells through miniTurbo Proximity Labeling by Harrison J. McNabb, Jianhua Zhang, Connor P. Jewell, Weiming Yang, Lisa M. Jenkins, William F. Simonds (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13628604.txt.
Description
Harrison McNabb and five co-authors published a neuroscience study in twenty twenty-six cataloguing the protein partners of G-beta-5, an oddball signaling protein whose mutations cause a multisystem developmental disorder. Unlike its relatives, it works away from the cell surface as well as at it, and its contacts in the cell interior and nucleus were unmapped. A proximity-labeling trick in living neuron-like cells changed that.
The tagged protein biotin-marked its neighbors, which mass spectrometry then identified. Forty-eight candidate partners emerged, most never reported before, many tied to neuronal development and function. The enriched traits mirror what G-beta-5 deficiency does in patients. The interactome gives the disorder's genetics a working parts list.
Catalog record
| CREATOR | Harrison J. McNabb, Jianhua Zhang, Connor P. Jewell, Weiming Yang, Lisa M. Jenkins, William F. Simonds |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |