Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics
Kristina A. Kostadinova, Jan L. Venne, Sona Krajcovicova, James Dodgson, Wouter F. J. Hogendorf, Thomas E. Nielsen, David Hymel, Hannah Bolt, Andie Collinson, Jason Day, Jefferson Revell, David R. Spring · 2026
Read Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics by Kristina A. Kostadinova, Jan L. Venne, Sona Krajcovicova, James Dodgson, Wouter F. J. Hogendorf, Thomas E. Nielsen, David Hymel, Hannah Bolt, Andie Collinson, Jason Day, Jefferson Revell, David R. Spring (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13628533.txt.
Description
Kristina A. Kostadinova and eleven colleagues present a modular kit for assembling medicines that switch on several hormone receptors at once, a strategy behind the newest obesity drugs. Published in 2026, their system replaces the usual one-off construction of each large fusion peptide with a flexible scaffold onto which parts can be clicked in sequence.
The scaffold is built on solid phase without intermediate purification and accepts up to three components, such as therapeutic peptides or units that extend a drug's life in the body. As proof, the team combined GLP-1 and amylin receptor activators into dual-acting constructs with adjustable dosing balance. The leads proved potent at both receptors in cell assays, and the authors offer the platform as a general route to multifunctional peptide medicines.
Catalog record
| CREATOR | Kristina A. Kostadinova, Jan L. Venne, Sona Krajcovicova, James Dodgson, Wouter F. J. Hogendorf, Thomas E. Nielsen, David Hymel, Hannah Bolt, Andie Collinson, Jason Day, Jefferson Revell, David R. Spring |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26277 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |