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Takahiro Hirayama, Kiyoka Omoto, Tamami Watanabe, Shinobu Matsubara, Naoto Yamamoto · 2026

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Description

Takahiro Hirayama and four co-authors reply to comments on their study of lymph flow imaging, in this 2026 response. Their study used contrast-enhanced ultrasound, injecting tiny bubbles under the skin to watch the lymph vessels of the leg carry fluid. Commentators had worried that the injection itself, its pressure and volume, might fake the two-way flow the team reported seeing.

The authors answer that the bubbles were injected at four points in the foot, far from where the camera watched the lower leg and thigh. Local pressure at such a distance, they argue, cannot explain movement seen upstream. They also agree with the commentators' reading of skin backflow as the lymph network remodeling itself to cope. The reply clarifies a methods detail the original report left thin and shows where the two sides of the exchange agree.

Catalog record

CREATORTakahiro Hirayama, Kiyoka Omoto, Tamami Watanabe, Shinobu Matsubara, Naoto Yamamoto
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE2 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13628243

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