Overuse of thrombopoietin receptor agonists driven by suboptimal response is associated with myelofibrosis in pediatric immune thrombocytopenia
Jingyao Ma, Zhenping Chen, Xiaoling Cheng, Yu Hu, Jin Jiang, Jie Ma, Hongyun Lian, Liqiang Zhang, Xinyue Ma, Xi Lin, Shuyue Dong, Chuo Li, Wanru Yao, Shasha Zhao, Yunyun Wei, Runhui Wu · 2026
Read Overuse of thrombopoietin receptor agonists driven by suboptimal response is associated with myelofibrosis in pediatric immune thrombocytopenia by Jingyao Ma, Zhenping Chen, Xiaoling Cheng, Yu Hu, Jin Jiang, Jie Ma, Hongyun Lian, Liqiang Zhang, Xinyue Ma, Xi Lin, Shuyue Dong, Chuo Li, Wanru Yao, Shasha Zhao, Yunyun Wei, Runhui Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13628019.txt.
Description
Jingyao Ma and co-authors studied a scarring risk tied to platelet-boosting drugs in children with a bleeding disorder, in this 2026 paper. In immune thrombocytopenia, the body destroys its platelets, leaving children prone to bruising and bleeding. A class of drugs that mimic the platelet growth signal has become standard second-line treatment. The drugs raise counts, but they enlarge the platelet-making cells of the marrow.
That growth can lay down fibers in the marrow, a change called myelofibrosis. In adults the scarring is usually mild and fades when the drug stops. The team examined children whose response was poor and who received more of the drugs for longer. Overuse driven by weak response, they found, tracked with more marrow scarring. Their work argues for restraint: when the drug is not working, pushing the dose may buy little and cost the marrow.
Catalog record
| CREATOR | Jingyao Ma, Zhenping Chen, Xiaoling Cheng, Yu Hu, Jin Jiang, Jie Ma, Hongyun Lian, Liqiang Zhang, Xinyue Ma, Xi Lin, Shuyue Dong, Chuo Li, Wanru Yao, Shasha Zhao, Yunyun Wei, Runhui Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |