Reconstitution of genome remodeling using Xenopus egg extracts
Katherine G. Lenz, Coral Y. Zhou · 2026
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Description
Katherine Lenz and Coral Zhou review frog egg extracts as a lab for genome remodeling in a paper from 2026. The eggs of the African clawed frog yield a cytoplasm packed with everything needed to build nuclei. Adding outside DNA triggers fast, repeatable chromatin assembly and replication. Researchers watch the process by microscopy, gels, or genomics. The system historically revealed how chromosomes are built and copied.
The review gathers the main assays the extract enables. Recent work stretches from division to differentiation transitions. New directions include using the system to study speciation and polyploidy. Biochemical control is the draw: reactions can be tweaked molecule by molecule. The authors map where the field can go next.
Catalog record
| CREATOR | Katherine G. Lenz, Coral Y. Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |