Development of functional spatial mapping of the tumour immune microenvironment (FuncO:TiME) in advanced melanomas
Emma Wagner, Samuel Legg, Christopher J Applebee, Amanda R Kirane, Julian Padget, Banafshé Larijani · 2026
Read Development of functional spatial mapping of the tumour immune microenvironment (FuncO:TiME) in advanced melanomas by Emma Wagner, Samuel Legg, Christopher J Applebee, Amanda R Kirane, Julian Padget, Banafshé Larijani (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13627726.txt.
Description
Emma Wagner and colleagues map not just where two immune checkpoint proteins sit in melanoma, but where they actually touch. Drugs that block the PD-1 and PD-L1 pair work by breaking that contact, yet clinics still dose by protein counts alone. Their method, FuncO:TiME, layers functional interaction mapping with tissue profiling on melanoma samples taken before and after checkpoint therapy, counting millions of pixel-level contacts.
The contact maps varied wildly across each tumor, in patterns the protein counts never hinted at. After treatment, contacts rose even where protein levels stood still, proof that the two measures can walk apart. Reading the handshake rather than the headcount, the authors argue, could one day guide who gets these drugs and how they are combined.
Catalog record
| CREATOR | Emma Wagner, Samuel Legg, Christopher J Applebee, Amanda R Kirane, Julian Padget, Banafshé Larijani |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |