Submolecular video-imaging of the Smc5/6 complex topologically bound to DNA
Kenichi Umeda, Yumiko Kurokawa, Noriyuki Kodera, Yasuto Murayama · 2026
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Description
Ring-shaped protein complexes that hug DNA organize whole chromosomes, yet watching one work has been nearly impossible. Kenichi Umeda and three co-authors film the Smc5/6 complex directly with high-speed atomic force microscopy, at detail fine enough to see its parts move on DNA.
At rest the complex sits in a narrow I shape with its arms aligned. When ATP binds, it opens into an O-shaped ring and grips DNA at its head domains. Burning the ATP traps the DNA inside the ring and slides it toward the hinge. The complex also bridged two DNA stretches at once and stabilized twisted DNA, compacting it. The authors say the footage shows how one ring switches between binding modes. The study appears in 2026.
Catalog record
| CREATOR | Kenichi Umeda, Yumiko Kurokawa, Noriyuki Kodera, Yasuto Murayama |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |