Comparison of ultrahigh- and low-pressure packing methods for preparation of 50 cm long capillary UHPLC columns
Tate A. Hancock, Robert T. Kennedy · 2026
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Description
Tate Hancock and Robert Kennedy compare two ways of packing long, thin tubes used in chemical analysis, in a study published in 2026. The tubes are filled with tiny beads that sort molecules as liquid flows through. One method packs them at very high pressure, and the other works at low pressure with far simpler gear.
The team packed tubes fifty centimeters long both ways and tested them on small molecules and on a mix of protein fragments. Shaking the low-pressure tubes with sound waves during packing helped them work better. In the end the cheap method matched the costly one, with sharp peaks and steady results from run to run. The authors present it as a less demanding route to high-quality tubes for labs.
Catalog record
| CREATOR | Tate A. Hancock, Robert T. Kennedy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |