Photocatalytic Proximity Labeling Maps RNA and Protein Subcellular Landscapes
Meihan Hou, Linao Ren, Xin Xi, Rongjie Zhu, Shengda Xie, Yaqian Liu, Xiaocheng Weng, Xiang Zhou, Yuhao Du · 2026
Read Photocatalytic Proximity Labeling Maps RNA and Protein Subcellular Landscapes by Meihan Hou, Linao Ren, Xin Xi, Rongjie Zhu, Shengda Xie, Yaqian Liu, Xiaocheng Weng, Xiang Zhou, Yuhao Du (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13625569.txt.
Description
Meihan Hou and co-authors tag near molecules with light to map cell rooms in a 2026 study. Where proteins and RNAs sit inside a cell shapes what the cell does. Their method, PhotoPL, parks a light catalyst in one cell room. A sleep-state probe rides with it. Light wakes the catalyst, which sprays short-lived tags that stick to near molecules. The tags then mark the room's protein and RNA sets for readout.
The team mapped two rooms this way: the power plant and the protein fold shop of the cell. Readouts matched known room sets with high faith. No gene edits are needed, so cells stay near whole. Rooms can swap by a plug-and-play swap of the aim piece. The authors pitch the kit for health and disease maps alike.
Catalog record
| CREATOR | Meihan Hou, Linao Ren, Xin Xi, Rongjie Zhu, Shengda Xie, Yaqian Liu, Xiaocheng Weng, Xiang Zhou, Yuhao Du |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |