MFSD2A in health and disease: lysolipid transport, barrier physiology, and translational boundaries
Jinheng Gan, Yang Chen, Lin Xin · 2026
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Description
Jinheng Gan, Yang Chen, and Lin Xin review MFSD2A, a transport protein that ferries fatty building blocks into the brain and other guarded tissues. The protein carries a fat molecule called DHA, vital for brain growth, across the blood-brain barrier while also keeping that barrier sealed. The review weighs evidence link by link, from transport chemistry to disease.
The firmest ground covers how the transporter grabs its cargo with sodium's help and how brain blood vessels use it during development. Children born with two broken copies develop small brains and severe developmental problems, the strongest human evidence of its role. Evidence from the eye, placenta, lung, kidney, and skin points to local jobs rather than one universal pathway. Hopes for cancer prediction or drug delivery through the barrier remain mostly associations so far. The authors map what is proven, what is tissue-specific, and what is still guesswork.
Catalog record
| CREATOR | Jinheng Gan, Yang Chen, Lin Xin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |