RBP-Driven RNA sorting and local translation establish the molecular identities of individual sensory axons
Elizabeth S. Silagi, Ezechukwu Nduka, Jesus Zuniga Paiz, Maria F. Pazyra-Murphy, Shamsuddin A. Bhuiyan, William Renthal, Rosalind A. Segal · 2026
Read RBP-Driven RNA sorting and local translation establish the molecular identities of individual sensory axons by Elizabeth S. Silagi, Ezechukwu Nduka, Jesus Zuniga Paiz, Maria F. Pazyra-Murphy, Shamsuddin A. Bhuiyan, William Renthal, Rosalind A. Segal (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13623950.txt.
Description
Elizabeth Silagi and six co-authors map how nerve fibers sort their cargo in a 2026 study of touch neurons. These neurons send one branch to the skin and one to the spinal cord, and each branch faces a different world, yet how the branches keep distinct traits has been unclear.
Using a method that tags the protein-making machines in each branch, the team found thousands of messages read mainly in one branch or in the cell body. Many code for ion channels and signal receivers that could set each branch's feel and repair skill. Two binding proteins stood out as traffic guides, one steering messages toward the skin branch and one toward the cord branch. Injury changed some of these local reads, hinting at how pain states may form.
Catalog record
| CREATOR | Elizabeth S. Silagi, Ezechukwu Nduka, Jesus Zuniga Paiz, Maria F. Pazyra-Murphy, Shamsuddin A. Bhuiyan, William Renthal, Rosalind A. Segal |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 102 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |