Sex-associated circadian signaling signatures in the lateral hypothalamus
Sara K. Pintwala, Patrick M. Fuller · 2026
Read Sex-associated circadian signaling signatures in the lateral hypothalamus by Sara K. Pintwala, Patrick M. Fuller (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13623931.txt.
Description
Sara Pintwala and Patrick Fuller chart how the brain's daily clock runs differently in female and male neurons of the lateral hypothalamus. This hub steers arousal, feeding, metabolism, stress, and the switch between sleep and waking, all on a twenty-four-hour rhythm. Sex differences in those behaviors are well known; their molecular roots inside this hub were not.
Using single-nucleus RNA sequencing, they read clock genes and related pathways in each defined neuron type from both sexes. The hub's overall architecture proved nearly identical. Differences were scattered and cell-type specific rather than global. The map tells future studies exactly which neurons to interrogate about sex and time of day.
Catalog record
| CREATOR | Sara K. Pintwala, Patrick M. Fuller |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |