Engineering small peptide secretion in Komagataella phaffii
Johanna Pirchner, Simon Arhar, Corinna Odar, Lisa Frühauf, Azra Kapetanović, Uma Isaković, Susanne Lux, Sven Heimhilcher, Andreas Winkler, Anton Glieder, Anita Emmerstorfer-Augustin · 2026
Read Engineering small peptide secretion in Komagataella phaffii by Johanna Pirchner, Simon Arhar, Corinna Odar, Lisa Frühauf, Azra Kapetanović, Uma Isaković, Susanne Lux, Sven Heimhilcher, Andreas Winkler, Anton Glieder, Anita Emmerstorfer-Augustin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13623913.txt.
Description
Johanna Pirchner and co-authors studied how to make a yeast host secrete very small peptides, in a 2026 paper. Small peptides are a growing class of medical drugs, but making them by chemistry has limits, so microbe factories draw interest. The yeast they used is a workhorse for secreted proteins, yet peptides under a set size slip through poorly and are hard to detect.
The team used a tiny tagged peptide of 23 building blocks as its test case. They varied chain length and the signal that sends a peptide out of the cell, and boosted parts of the export machinery. A random mutation screen found new genes that sway secretion. The tricks then carried to three other peptides.
Catalog record
| CREATOR | Johanna Pirchner, Simon Arhar, Corinna Odar, Lisa Frühauf, Azra Kapetanović, Uma Isaković, Susanne Lux, Sven Heimhilcher, Andreas Winkler, Anton Glieder, Anita Emmerstorfer-Augustin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |