Serum uric acid variability and short-term mortality in chronic kidney disease: a retrospective cohort study with independent replication in MIMIC-IV
Fan Zhu, Wenyuan Gan, Wenli Chen, Xingruo Zeng · 2026
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Description
Fan Zhu and three colleagues published a cohort study in two thousand twenty-six on uric acid swings in kidney disease. Average uric acid is a known risk marker, but how much it bounces between visits may signal instability. Its link to near-term death in chronic kidney disease was unclear.
Over ten thousand five hundred adults with at least three uric acid readings were followed. Higher swing levels tracked with clearly higher short-term mortality, even after full adjustment. No such link appeared for kidney events or heart events. Most deaths came within ninety days, and the signal vanished beyond that window. A large intensive care database reproduced the short-term pattern. The authors read variability as a warning sign of fragile health.
Catalog record
| CREATOR | Fan Zhu, Wenyuan Gan, Wenli Chen, Xingruo Zeng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |