Peripheral blood transcriptomes and a single-cell atlas suggest a monocyte-associated immune recovery-failure axis in STEMI
Qi Cheng, Qunxing Li, Delu Yin, Federica Limana · 2026
Read Peripheral blood transcriptomes and a single-cell atlas suggest a monocyte-associated immune recovery-failure axis in STEMI by Qi Cheng, Qunxing Li, Delu Yin, Federica Limana (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13623093.txt.
Description
Qi Cheng and three co-authors build a gene-based picture of why some heart attack patients calm their inflammation after treatment while others do not. The attack type studied, STEMI, is the most severe form, and reopening the artery does not end the immune storm for everyone. The team worked from public blood gene data rather than new patients.
They combined six blood data sets and one single-cell data set, then built an axis running from acute inflammation toward recovery. Eighty-one patients in the main cohort split into recovery and recovery-failure groups by their gene patterns. An eighteen-gene module tied to monocytes, a frontline immune cell, marked the failure group and faded as patients recovered in other cohorts. Single-cell data confirmed the signal sat in monocytes. The authors stress the tool describes a pattern for testing, not a proven way to predict outcomes.
Catalog record
| CREATOR | Qi Cheng, Qunxing Li, Delu Yin, Federica Limana |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |