Linear DNA expression cassette encapsulated in lipid nanoparticles confers complete protection against influenza A virus in mice
Danh C. Lai, The N. Nguyen, Giao P. Trinh, Hiep L. X. Vu · 2026
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Description
Danh Lai, The Nguyen, Giao Trinh, and Hiep Vu test a new flu vaccine format in mice, in a 2026 study. DNA vaccines usually ride on bacterial plasmids, which carry antibiotic resistance genes that raise safety worries. The team instead used a short linear DNA cassette made by PCR, carrying the hemagglutinin gene of an H1N1 flu virus and no bacterial baggage. The cassette was packed into lipid nanoparticles for delivery.
A standard circular plasmid with the same gene served as the comparison. The nanoparticle cassette matched the plasmid's physical traits and, as the title reports, gave complete protection against influenza A in the mouse model. A cleaner DNA format that protects as well as plasmids could ease safety review for future vaccines.
Catalog record
| CREATOR | Danh C. Lai, The N. Nguyen, Giao P. Trinh, Hiep L. X. Vu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |