The Influence of Age on Notch1 and VEGF‐A Responses During Exercise
Brooke R. Shepley, Lana H. Yacoub, Nicholas J. Lester, Rian A. Grassi, Jessica N. Kenney, Kevin J. Milne, Anthony R. Bain, Karla Margarita Moreno-Tamayo · 2026
Read The Influence of Age on Notch1 and VEGF‐A Responses During Exercise by Brooke R. Shepley, Lana H. Yacoub, Nicholas J. Lester, Rian A. Grassi, Jessica N. Kenney, Kevin J. Milne, Anthony R. Bain, Karla Margarita Moreno-Tamayo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13621830.txt.
Description
Brooke R Shepley and colleagues explore whether age changes how two blood vessel signals respond to hard exercise. The signals, Notch1 and VEGF-A, help keep the inner lining of vessels healthy and react to the friction of flowing blood. The team measured them in healthy adults before and after a peak cycling test.
Twenty-nine adults aged twenty to sixty-five gave blood at rest, right after exercise, and after fifteen minutes of recovery. The measured piece of Notch1 stayed flat across exercise on average, yet it ran higher in older adults and its change after exercise varied with age. That change also tracked the thickness of the neck artery wall. VEGF-A showed no clear pattern at all. The authors read the contrast as a sign that aging alters one vessel pathway while leaving the other largely untouched.
Catalog record
| CREATOR | Brooke R. Shepley, Lana H. Yacoub, Nicholas J. Lester, Rian A. Grassi, Jessica N. Kenney, Kevin J. Milne, Anthony R. Bain, Karla Margarita Moreno-Tamayo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |