Microwave-Enabled Oxidative Alkoxycyclization of 2′-Aminochalcones by Gold Catalysis
Chandrasekar Praveen, Gabriel de Paula Bueno, Franco Jazon Caires, Giuliano C. Clososki · 2026
Read Microwave-Enabled Oxidative Alkoxycyclization of 2′-Aminochalcones by Gold Catalysis by Chandrasekar Praveen, Gabriel de Paula Bueno, Franco Jazon Caires, Giuliano C. Clososki (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13621808.txt.
Description
Chandrasekar Praveen and colleagues present a chemistry method that builds a family of compounds called quinolines, ring-shaped molecules found in many medicines and natural products. Their route starts from simpler building blocks known as 2'-aminochalcones and uses a gold salt as a catalyst, meaning a helper that speeds a reaction without being used up. Microwaves supply the heat.
In the reaction, an alcohol serves both as the liquid medium and as a reacting partner, so no extra oxidant is needed. Straight, branched, ring-shaped, and plant-derived alcohols all worked, giving products in fair to good yields. The route also made two natural alkaloids in one step and could be steered toward related ring systems. Early tests of how the reaction proceeds suggest the gold catalyst drives two steps in a row, which helps explain the clean results.
Catalog record
| CREATOR | Chandrasekar Praveen, Gabriel de Paula Bueno, Franco Jazon Caires, Giuliano C. Clososki |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |