Multinational pharmacovigilance assessment of drug-associated esophageal ulceration and perforation: evidence from FAERS, JADER, and Canada Vigilance
Lihua Zhang, Xinchi Luan, Caiqi Liu, Xiaofei Xin, Xiaolei Zhang, Shufen Zhao, Wensheng Qiu · 2026
Read Multinational pharmacovigilance assessment of drug-associated esophageal ulceration and perforation: evidence from FAERS, JADER, and Canada Vigilance by Lihua Zhang, Xinchi Luan, Caiqi Liu, Xiaofei Xin, Xiaolei Zhang, Shufen Zhao, Wensheng Qiu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13621738.txt.
Description
Some medicines can ulcerate or even tear the swallowing tube, a rare but serious harm. Zhang and co-authors scan three large side-effect reporting systems, from the United States, Japan, and Canada, covering 2004 to 2025. They count reports for these events and test which drugs appear far more often than chance would predict.
The United States database held 8,061 matching reports, and the strongest signals were for doxycycline, alendronic acid, and clindamycin, all known pill-injury drugs. Patterns in the other two systems overlapped but differed. The authors stress the results are early signals, not proof of risk rates or cause.
Catalog record
| CREATOR | Lihua Zhang, Xinchi Luan, Caiqi Liu, Xiaofei Xin, Xiaolei Zhang, Shufen Zhao, Wensheng Qiu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |