Association of anhedonia with brain-derived neurotrophic factor and oxidative stress in bipolar disorder
Xueyan Zhu, Peiyun Zhang, Chao Liu, Yao Zhang, Xiaoxiao Wang, Xin Li, Daofeng Lu, Fang Guo, Yuan Yao, Jiayu Zhu, Chengjia Shen, Chongze Wang, Ping Zhang, Qi Yan, Zhenghui Yi, Qinyu Lv, Peijuan Wang · 2026
Read Association of anhedonia with brain-derived neurotrophic factor and oxidative stress in bipolar disorder by Xueyan Zhu, Peiyun Zhang, Chao Liu, Yao Zhang, Xiaoxiao Wang, Xin Li, Daofeng Lu, Fang Guo, Yuan Yao, Jiayu Zhu, Chengjia Shen, Chongze Wang, Ping Zhang, Qi Yan, Zhenghui Yi, Qinyu Lv, Peijuan Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13621658.txt.
Description
Xueyan Zhu led a large team hunting body-chemistry links to anhedonia, the flattened ability to feel pleasure, in bipolar depression, in 2026. Anhedonia predicts worse outcomes and resists standard drugs, but its chemistry is unsettled. The study compared eighty-five bipolar patients, sixty-one of them depressed, with eighty-eight healthy volunteers. The team checked pleasure capacity, childhood adversity, oxidative stress markers, and BDNF, a growth factor that feeds neurons.
Depressed patients reported far less pleasure, both in anticipation and in the moment, alongside more anxiety and more childhood adversity. One antioxidant enzyme, catalase, differed clearly between groups. Within the depressed group, higher BDNF and catalase levels tracked with lower enjoyed pleasure, an unexpected negative link. BDNF stood out as a predictor of that pleasure loss in the final model. The authors argue anhedonia in bipolar disorder is partly written in this chemistry, opening a route toward biomarker-guided treatment.
Catalog record
| CREATOR | Xueyan Zhu, Peiyun Zhang, Chao Liu, Yao Zhang, Xiaoxiao Wang, Xin Li, Daofeng Lu, Fang Guo, Yuan Yao, Jiayu Zhu, Chengjia Shen, Chongze Wang, Ping Zhang, Qi Yan, Zhenghui Yi, Qinyu Lv, Peijuan Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29005 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |