Spleens With Disseminated Lymphoma Exhibit Higher Standardized Uptake Value Maximum, Metabolic Tumor Volumes, and Total Lesion Glycolysis on Fluorine‐18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography

Description

Jesse Johnson, Lynn Griffin, Kathryn Vickery, and Elissa Randall asked whether PET scan numbers can reveal lymphoma hiding in a dog's spleen without a needle. Staging canine lymphoma normally leans on sampling organs directly, yet spleen sampling carries risk and effort. The team followed dogs through chemotherapy with repeated FDG PET/CT scans, outlining the spleen each time and comparing three metabolic measures against the organ's actual cell samples.

Seven dogs contributed seventeen spleen samples. Spleens harboring lymphoma showed clearly higher uptake and tumor-volume measures than spleens with benign findings. Two thresholds separated the groups reliably: the peak uptake value above a modest cutoff, and metabolic tumor volume above a set level. Total lesion glycolysis also ran higher in involved spleens. The authors suggest these scan cutoffs could support noninvasive staging, treatment monitoring, and relapse checks, while cautioning that the group was small and needs confirmation.

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Source: https://europepmc.org/article/MED/PMC13621582