Molecular and Cellular Underpinnings of Primary Hypertension: An Integrative Mechanistic Framework
Dima Nasrallah, Alaa Abdelhamid, Omar Tluli, Yaman Al‐Haneedi, Mera Abu Hussien, Ali H Eid · 2026
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Description
Dima Nasrallah and five colleagues present high blood pressure as a whole-body disorder rather than a plumbing problem in one organ. Primary hypertension drives heart attacks, strokes, and early death worldwide, yet its machinery is only partly mapped. Their review organizes the disease around three engines that feed each other.
The first engine is the hormone system that manages salt and vessel tone, the renin-angiotensin-aldosterone network. The second is the central nervous system, whose stress wiring keeps pressure raised. The third is inflammation paired with oxidative stress, which scars vessels and kidneys alike. Around these engines orbit familiar contributors: salty diets, salt-sensitive bodies, disturbed gut microbes, broken sleep-wake rhythms, and insulin resistance. Each acts by pushing the central three. The authors argue that treatments aimed upstream at the drivers should beat chasing single numbers. They frame the model as a guide for prevention research.
Catalog record
| CREATOR | Dima Nasrallah, Alaa Abdelhamid, Omar Tluli, Yaman Al‐Haneedi, Mera Abu Hussien, Ali H Eid |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 87 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |