Sesame Immunotherapy: A Systematic Review and Narrative Synthesis
Joanna Zielińska, Katarzyna Kunkiel, Anna Krupa‐Łaska, Marek Kulus, Katarzyna Grzela · 2026
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Description
Joanna Zielińska and four colleagues reviewed immunotherapy for sesame allergy, a food allergy known for severe reactions and rarely fading on its own. Avoidance is today's only defense, so researchers have begun feeding patients tiny, rising doses to retrain the immune system. The reviewers gathered every study of sesame immunotherapy in diagnosed patients through August 2025 and graded its quality.
Nine studies qualified, mostly small cohorts and case series rather than trials. Oral therapy with sesame alone desensitized most patients, with success rates roughly between eighty-five and ninety-seven percent across varied protocols and ages. Lasting tolerance after stopping was documented in only a few, mainly children's, groups. Side effects were mostly mild or moderate, severe reactions needing adrenaline stayed uncommon, and no deaths occurred. Adding an antibody drug helped high-risk adults tolerate treatment. The authors call the results promising yet preliminary, asking for proper randomized trials.
Catalog record
| CREATOR | Joanna Zielińska, Katarzyna Kunkiel, Anna Krupa‐Łaska, Marek Kulus, Katarzyna Grzela |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |