Running‐based rehabilitation does not improve muscle function after volumetric muscle loss despite improving hindlimb weight‐bearing asymmetry in mice
Angela S Bruzina, Molly R Weberg, Ryan J Willoughby, Gordon L Warren, Jarrod A Call, Sarah M Greising · 2026
Read Running‐based rehabilitation does not improve muscle function after volumetric muscle loss despite improving hindlimb weight‐bearing asymmetry in mice by Angela S Bruzina, Molly R Weberg, Ryan J Willoughby, Gordon L Warren, Jarrod A Call, Sarah M Greising (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13621433.txt.
Description
Angela S Bruzina and five colleagues tested whether uneven limb loading explains why exercise rehab disappoints after volumetric muscle loss, an injury where a chunk of muscle is simply gone. One suspicion was that animals spare the injured leg, starving it of the loading that drives recovery. Twenty-four young mice were split into uninjured runners, injured non-runners, and injured runners with free wheel access for six weeks.
Injured runners did even out their weight bearing until it matched healthy runners, exactly the adaptation coaches would want. Muscle function, though, stayed stubbornly impaired, and the bone next to the injury gained nothing either. Loading, the authors conclude, was never the bottleneck. Something inside the remaining muscle blocks recovery despite normal use, so future rehab research should hunt that mechanism instead of chasing symmetry.
Catalog record
| CREATOR | Angela S Bruzina, Molly R Weberg, Ryan J Willoughby, Gordon L Warren, Jarrod A Call, Sarah M Greising |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |