Effect of Herbal Extracts on Antituberculosis Drug‐Induced Hepatotoxicity: A Systematic Review
Surthi M Ravedar, Kranthi Kiran Akula, Kalesh M Karun, Flemin Felix, Kamran Zaman, Jyothi Bhat, Subarna Roy, Lissinda H Du Plessis · 2026
Read Effect of Herbal Extracts on Antituberculosis Drug‐Induced Hepatotoxicity: A Systematic Review by Surthi M Ravedar, Kranthi Kiran Akula, Kalesh M Karun, Flemin Felix, Kamran Zaman, Jyothi Bhat, Subarna Roy, Lissinda H Du Plessis (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13621401.txt.
Description
Surthi M Ravedar and seven colleagues reviewed animal studies on whether plant extracts can shield the liver from tuberculosis drugs. First-line TB medicines cure the infection but injure the liver often enough to limit treatment. Following standard review practice, the team searched three databases for live-animal studies of herbal protection and scored their quality with an animal-research bias tool.
Sixty-eight studies made the cut. Protection varied widely by plant and study, yet three species stood out for cutting liver enzyme leaks and bilirubin while restoring antioxidant defenses in the tested animals. Those three were a ridged gourd, henna, and a wild melon relative. The reviewers think antioxidant and cell-protective chemistry explains the benefit, though exact mechanisms stay murky. They call for careful dosing and safety work, and eventually human trials, before any extract joins TB treatment.
Catalog record
| CREATOR | Surthi M Ravedar, Kranthi Kiran Akula, Kalesh M Karun, Flemin Felix, Kamran Zaman, Jyothi Bhat, Subarna Roy, Lissinda H Du Plessis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |