AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen · 2026
Read AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells by Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13621201.txt.
Description
Mingtian Ding and twelve colleagues found a chemical tag that lets brain tumor stem cells dodge a copper-based death. Glioblastoma is notorious for returning after treatment, driven by stem-like cells that resist therapy. Cuproptosis, a death route where copper makes mitochondrial proteins clump, should threaten such cells, yet they survive it. Profiling their protein tags pointed to one enzyme carrying a lactate-based mark.
One protein adds the mark using lactate, and another removes it. The mark leaves the enzyme's machinery intact but throttles a partner complex, cutting the fatty tags copper needs to trigger clumping. Erasing the mark restored the tags and made the cells sensitive to a copper-carrying drug again. Blocking lactate production, boosting the removing protein, or aiming a peptide at the marked spot all strengthened the drug in patient-derived and mouse brain tumor models. The authors name the axis a druggable target.
Catalog record
| CREATOR | Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |