β-cell 14-3-3-ζ and sex are key regulators of α-cell form and function
Rahaf Shishani, Rosalinda Moreno, Madelynn E Agabao-Tucker, Sofie E Dinglasan, Jessica Miranda Bustamante, Emily Eddy, Anna Jackson, Melanie A Reuter, Mara K Hon, Mark O Huising, Gareth E Lim, Bethany P Cummings · 2026
Read β-cell 14-3-3-ζ and sex are key regulators of α-cell form and function by Rahaf Shishani, Rosalinda Moreno, Madelynn E Agabao-Tucker, Sofie E Dinglasan, Jessica Miranda Bustamante, Emily Eddy, Anna Jackson, Melanie A Reuter, Mara K Hon, Mark O Huising, Gareth E Lim, Bethany P Cummings (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13621187.txt.
Description
Rahaf Shishani and a large team show how a beta cell protein and sex jointly rule alpha cell form and hormone output in the pancreas. Alpha cells vary in which hormones they make, and some can be coaxed to make a prized gut hormone. The beta protein was known to curb that switch in lab cells.
Mice that lack alpha made hormone coped worse with a fat diet. Removing the beta protein helped glucose control in males only in meal tests, and raised alpha counts in males while lifting hormone output in both sexes. Human data show more alpha cells in females too.
Catalog record
| CREATOR | Rahaf Shishani, Rosalinda Moreno, Madelynn E Agabao-Tucker, Sofie E Dinglasan, Jessica Miranda Bustamante, Emily Eddy, Anna Jackson, Melanie A Reuter, Mara K Hon, Mark O Huising, Gareth E Lim, Bethany P Cummings |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |