Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies
Toshiki Otoda, Hideto Nakajima, Tadateru Takayama · 2026
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Description
Toshiki Otoda, Hideto Nakajima, and Tadateru Takayama review mitohormesis in a 2026 paper linking metabolism to brain aging. Mitohormesis means mild stress on mitochondria, the power units of cells, can trigger defenses that leave cells hardier. Too much stress instead swamps them and harms tissue.
Obesity and type 2 diabetes raise dementia risk, and long metabolic strain wears down how mitochondria check their own quality in animal studies. The replies span stress signals, reuse of worn parts, and notes passed between organs. In Alzheimer's, failed mitochondria and plaque buildup may feed each other in a loop. Exercise, fasting patterns, and several diabetes drugs engage these pathways, though direct human proof stays thin.
Catalog record
| CREATOR | Toshiki Otoda, Hideto Nakajima, Tadateru Takayama |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |