Plasma Exchange for Hantavirus Pulmonary Syndrome: A Mechanistic Case for an Untested Intervention

Menatalla Nadim, Yasamin Mirzabeigi, Yamac Akgun · 2026

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Description

Menatalla Nadim, Yasamin Mirzabeigi, and Yamac Akgun make a mechanistic case for testing plasma exchange in hantavirus pulmonary syndrome, a lung and heart illness that kills roughly four in ten patients. No drug has proven effective against it. The disease's damage runs through the blood plasma itself, where cytokines, viral proteins, and immune complexes injure vessel linings and flood the lungs.

Plasma exchange physically clears those circulating drivers and already serves many approved uses with a similar logic. The authors argue timing would matter most early in the heart-lung phase, and that replacing removed plasma with donor plasma could also help the disease's clotting problems. They set their idea honestly against the mixed record of plasma exchange in similar conditions. A recent Andes virus outbreak on a cruise ship prompted the piece, and they stress that only a systematic case series could test the idea.

Catalog record

CREATORMenatalla Nadim, Yasamin Mirzabeigi, Yamac Akgun
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE22 KB
LICENSEhttps://creativecommons.org/licenses/by/4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/article/MED/PMC13620195

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