Tuning intracellular immunity by Nodamura virus B2 protein enhances self-amplifying RNA activity
Raul Y. Sanchez-David, Josephine Nemegeer, Hoang Duy Le, Eva Žusinaite, Livia Spiga, Amanda Gonçalves, John S. Tregoning, Andres Merits, Pierre V. Maillard · 2026
Read Tuning intracellular immunity by Nodamura virus B2 protein enhances self-amplifying RNA activity by Raul Y. Sanchez-David, Josephine Nemegeer, Hoang Duy Le, Eva Žusinaite, Livia Spiga, Amanda Gonçalves, John S. Tregoning, Andres Merits, Pierre V. Maillard (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13620136.txt.
Description
Raul Y Sanchez-David and eight colleagues found a way to make self-amplifying RNA work harder inside cells without muting its immune spark. Such RNA copies itself after delivery, so it can produce a target protein for longer at lower doses, which suits vaccines. The catch is that cells sense its double-stranded forms and shut production down. Adding a small protein from Nodamura virus, called B2, changed that balance.
In stem cells, B2 limited the chopped viral RNA fragments that mark an active antiviral defense. In ordinary body cells, it stopped a sensor protein from halting protein production. The viral protein gathers the double-stranded RNA at the cell's edge, hiding it from defenders, yet the interferon alarm still sounds, preserving the built-in immune stimulation. The authors propose building B2 into future self-amplifying vaccines and therapies.
Catalog record
| CREATOR | Raul Y. Sanchez-David, Josephine Nemegeer, Hoang Duy Le, Eva Žusinaite, Livia Spiga, Amanda Gonçalves, John S. Tregoning, Andres Merits, Pierre V. Maillard |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |