ZIP1-dependent lymphatic adaptations facilitate lymph node metastasis of pancreatic cancer
Ruoyang Chen, Kaili Zhang, Jiajia Wan, Yuanyuan Yang, Linlin Wang, Xiangjing Miao, Qingqing Fang, Yu Hu, Xixi Duan, Xiaohan Lou, Xiaohan Yao, Anqi Li, Linyu Zhu, Zhihai Qin, Chen Ni · 2026
Read ZIP1-dependent lymphatic adaptations facilitate lymph node metastasis of pancreatic cancer by Ruoyang Chen, Kaili Zhang, Jiajia Wan, Yuanyuan Yang, Linlin Wang, Xiangjing Miao, Qingqing Fang, Yu Hu, Xixi Duan, Xiaohan Lou, Xiaohan Yao, Anqi Li, Linyu Zhu, Zhihai Qin, Chen Ni (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13618232.txt.
Description
Ruoyang Chen and co-authors study how pancreatic cancer spreads through lymph vessels in this 2026 paper. Tumors reach the lymph nodes by passing through those vessels, which must adapt to let them through. The team focused on a zinc transporter protein, called ZIP1, in the vessel walls.
In mice lacking the transporter, vessel walls stayed tighter and spread to the nodes fell. The team traced the effect to sugar burning in vessel cells, which under the transporter makes acid that loosens a key seal protein. Blocking the transporter raised that seal protein and cut tumor cell crossing. Mice with the gene removed only in lymph vessels showed the same tighter barrier. Human tumors with the transporter in their lymph vessels also spread more, marking a possible drug target.
Catalog record
| CREATOR | Ruoyang Chen, Kaili Zhang, Jiajia Wan, Yuanyuan Yang, Linlin Wang, Xiangjing Miao, Qingqing Fang, Yu Hu, Xixi Duan, Xiaohan Lou, Xiaohan Yao, Anqi Li, Linyu Zhu, Zhihai Qin, Chen Ni |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |