RAGE signaling in acute myocardial infarction: sRAGE as a dynamic biomarker and emerging therapeutic target
Aneta Aleksova, Elena Vianello, Paola Primignani, Massimiliano M. Corsi Romanelli, Lucia La Sala, Antonio P. Beltrami, Francesca Fumagalli, Elena Dozio · 2026
Read RAGE signaling in acute myocardial infarction: sRAGE as a dynamic biomarker and emerging therapeutic target by Aneta Aleksova, Elena Vianello, Paola Primignani, Massimiliano M. Corsi Romanelli, Lucia La Sala, Antonio P. Beltrami, Francesca Fumagalli, Elena Dozio (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13617643.txt.
Description
Aneta Aleksova and co-authors review a signaling pathway in heart attacks in a 2026 paper on RAGE, the receptor for advanced glycation end products. When this receptor switches on during a heart attack, it feeds inflammation and oxidative stress, worsening the injury and the heart's later remodeling.
A soluble form of the receptor circulates in blood and might serve as a marker of pathway activity. Studies link its levels to heart damage and severity, but results conflict, partly because isoforms, timing, and lab methods differ between studies. No validated cut-off exists yet. The authors also weigh early ideas for blocking the pathway as treatment.
Catalog record
| CREATOR | Aneta Aleksova, Elena Vianello, Paola Primignani, Massimiliano M. Corsi Romanelli, Lucia La Sala, Antonio P. Beltrami, Francesca Fumagalli, Elena Dozio |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |