Tissue‐specific recombination‐activated clonal and inducible transcription (TRAC‐IT) enables controlled gene activation in stably marked tissues
Tristan Wijsman, Jana Wittmer, Robert Winter, Teun Bruins, Arjan van Zeijl, Harm Nijveen, Ben Scheres, Renze Heidstra · 2026
Read Tissue‐specific recombination‐activated clonal and inducible transcription (TRAC‐IT) enables controlled gene activation in stably marked tissues by Tristan Wijsman, Jana Wittmer, Robert Winter, Teun Bruins, Arjan van Zeijl, Harm Nijveen, Ben Scheres, Renze Heidstra (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13617364.txt.
Description
Tristan Wijsman and co-authors build a two-step gene switch for plant research that stays on in a patch of tissue even after the cells change jobs. Their 2026 paper solves a snag in current tools. A switch tied to a cell type dies when the cell sheds that type, which breaks long studies of growth.
Their system, called TRAC-IT, works in two moves. A first drug dose flips a DNA switch in a chosen tissue, marking a clone of cells with a glow protein and arming a second switch inside them. A later dose of a second drug then turns on any target gene, but only inside the marked clone. Since the arming is written into the DNA, daughter cells keep it.
Catalog record
| CREATOR | Tristan Wijsman, Jana Wittmer, Robert Winter, Teun Bruins, Arjan van Zeijl, Harm Nijveen, Ben Scheres, Renze Heidstra |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |