Successful Engraftment Following Blinatumomab and Donor-Derived Buffy Coat Infusion in a Patient With Relapsed B-cell Acute Lymphoblastic Leukemia and High-Level Donor-Specific Anti-HLA Antibodies: A Case Report
Takahiro Maeta, Kazuya Asano, Kentaro Kobayashi, Tsuyoshi Sato, Shigeki Ito · 2026
Read Successful Engraftment Following Blinatumomab and Donor-Derived Buffy Coat Infusion in a Patient With Relapsed B-cell Acute Lymphoblastic Leukemia and High-Level Donor-Specific Anti-HLA Antibodies: A Case Report by Takahiro Maeta, Kazuya Asano, Kentaro Kobayashi, Tsuyoshi Sato, Shigeki Ito (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13616611.txt.
Description
Takahiro Maeta and co-authors published a case report in 2026 on a woman with relapsed blood cancer who needed a second stem cell transplant. Her own antibodies attacked the donor cells from her son, which can make a transplant fail. The team had to lower those antibodies before the new cells went in.
Antibody drugs and two rounds of a targeted therapy cut the levels a lot, though one stayed high. A day before the transplant they infused a small batch of the donor's white blood cells to soak up what was left. The new cells settled by day nine, and the harmful antibodies were gone by day thirty-three. No graft failure or severe graft-versus-host disease followed.
Catalog record
| CREATOR | Takahiro Maeta, Kazuya Asano, Kentaro Kobayashi, Tsuyoshi Sato, Shigeki Ito |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 17 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |