Deciphering the Medicinal Chemistry Aspects of Akt Inhibitors for the Management of Cancer: Structure–Activity Relationship Frameworks, Landscapes, and Optimization Approaches
Mayur S. Dhangar, Mahesh B. Palkar · 2026
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Description
A protein called Akt helps cells grow, and when its path runs out of control it can drive cancer. Mayur Dhangar and Mahesh Palkar review drugs built to block that protein in this 2026 paper. Over the past twenty years, chemists have made many such blockers, called Akt inhibitors. The review sorts them by the shape of their core parts and by how well each shape works.
The authors explain tricks that made some blockers stronger or more selective, such as locking a shape in place or joining two designs into one. Named drugs such as capivasertib and ipatasertib show how small shape changes shaped success. The review also covers how the body handles these drugs. That combined picture can guide chemists who design the next round of blockers.
Catalog record
| CREATOR | Mayur S. Dhangar, Mahesh B. Palkar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 142 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |