Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu · 2026
Read Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors by Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13616403.txt.
Description
Yi-Ming Liu and colleagues engineer an injectable gel depot that starves large liver tumours of glutamine while carrying two attack payloads, aiming to fix the uneven cooking of microwave ablation. Big liver tumours often survive ablation because heat spreads patchily and the leftover zone suppresses immunity. The gel forms in place through a catalytic setting reaction and holds a glutamine-blocking drug plus a sound-activated agent.
Under microwave heat plus ultrasound, the depot cuts the tumour's antioxidant defences and its energy supply lines at once. The combined stress wrecks the power plants, the protein workshop, and the DNA of cancer cells, triggering a mixed death program and waking immune alarms. Full coverage of a large tumour, not just its centre, is the prize: fewer survivors left to regrow.
Catalog record
| CREATOR | Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |